Academic Salon (XII)

SPEAKER: Congli Yuan

Professor, Ph.D. PI

Department of Animal Science, SAB

【Selected Publications】

Chunyan Wang, Haoran Zhang, Jiaqi Fu, Meng Wang, Yuhao Cai, Tianyun Ding, Jiezhang Jiang, Xiaoyun Liu, Jane E Koehler,Congli Yuan*. Bartonella type IV secretion effector BepC induces stress fiber formation through activation of GEF-H1. PLoS pathogens. 2021:28 (1):e1009065. doi: 10.1371/journal.ppat.1009065.
Wang C, Fu J, Wang M, Cai Y, Hua X, Du Y, Yang Z, Li Y, Wang Z, Sheng H, Yin N, Liu X, Koehler JE, Yuan C. Bartonella quintana type IV secretion effector BepE-induced selective autophagy by conjugation with K63 polyubiquitin chain. Cell Microbiol. 2019;21(4):e12984.
Jiehua Hong, Yan Li, Xiuguo Hua，Yajie Bai，Chunyan Wang，Zhibiao Yang，Yuming Du，Congli Yuan*. Lymphatic Circulation Disseminates Bartonella Infection Into Bloodstream，J Infectious Dis, 2017. 215:303~311
Caixia Zhu，Yajie Bai，Qiyong Liu，Dongmei Li，Jiehua Hong，hibiao Yang，Li Cui，Xiuguo Hua, Congli Yuan*. Depolymerization of cytokeratin intermediate filaments facilitates intracellular infection of HeLa cells by Bartonella henselae. J Infectious Dis, 2013.5.207:1397~1405

TIME ：12:40-13:30 Apr 14th, 2021 (Wednesday)

VENUE：Room 104, Building B, School of Agriculture and Biology

ORGANIZER：Office of Discipline and Science & Technology, SAB; Young Teachers Association, SAB

TITTLE: Intruder below the Radar: Pathogenesis of Bartonella

ABSTRACT:

Bartonella is the causing pathogen of Cat Scratch Diseases in humans. Intracellular replication of Bartonella in HUVECs causes the persistent bacteremia. Our study confirmed type 4 secretion system effector BepC induces stress fiber formation and cell protrusion through activation of GEF-H1 in HUVECs, subsequently, envelopes Bartonella aggregates to form a unique structure, called "invasome", under the synergistic effector with BepF. Formation of invasome benefits intracellular survival of Bartonella because invasome can block the fuse with lysosome. The cooperative mechanism of BepF with BepC on formation of invasome, however, has not been elucidated. Our studies are focusing on the exploration of mechanism how invasome is formed, which is expected to shed light on our understanding to the pathogenesis of Bartonella.

Academic Salon (XII)

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