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MENG HE

       MENG HE
       Ph.D/ Professor/ Head                                                
       Department of Animal Science
       Tel: 86-21-34206146 (O), 15801798349（M）
       E-mail: menghe@sjtu.edu.cn

     Address: Department of Animal science, College of School of  Agriculture and Biology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, P. R. China. 200240.

 

 


Education


Ph.D. Northeast Agricultural University, Harbin, P.R. China. 1999.9 – 2002.7
         Major: Animal Genetics & Breeding.
M. S. Inner Mongolia Agricultural University, Huhhot, P. R. China. 1986.9 – 1989.7

         Major: Animal Genetics and Breeding
B. S. Inner Mongolia Agricultural University, Huhhot, P. R. China.1982.9 – 1986.7
         Major: Animal Science

 


PROFESSIONAL EXPERIENCE 


Professor: Shanghai Jiao Tong University, P. R. China. 2012-Present
Associate Professor: Inner Mongolia University for Nationalities, P. R. China. 1998-2002  
Lecture: Inner Mongolia University for Nationalities, P. R. China. 1989-1998
Visiting scholar: Virginia Tech, USA. 2007、2011
Visiting scholar: TNO Quality of Life，Netherlands Organisation for applied scientific research, 
Netherlands. 2010

 


PROFESSIONAL SOCIETIES


Director: Poultry Science Branch, Animal Husbandry & Veterinary Medicine Society of P. R. ,China. 2005-present
Director: Shanghai Society for Cell Biology, P. R. China. 2013-present
Member: China Branch, World's Poultry Science Association (WPSA). 2005-present
Member: Bioinformation Society of P. R. China. 2001-present
Member: Animal Genetics & Breeding Branch, Animal Husbandry & Veterinary Medicine Society of P. R. China. 9/1995- present

 


RESEARCH INTERESTS


MENG’s laboratory main research focuses are: 


— Poultry Genetics and Breeding


Genetic variation contribute majority of the phenotypic variations in domestic animals. We focuses on using quantitative and molecular genetics methods to mapping genes and quantitative trait loci. Apply markers assistant selection (MSS)or whole genome selection(WGS) to animal breeding in order to improve economically-important characters in chicken or other domestic animals. 


— Animal Genomics 


To better understand the genetic basis, we have finished whole genome sequencing of multiple animals used the latest next-generation sequencing technique, as the wild and domestic bactrian camel, the wild horse (Przewalski’s horse) the domestic horse (Mongolian horse), the donkey and asiatic wild ass, the domestic goose and anser cygnoides. Through the comparative genomics analyses
and computational tools to understanding of the gene variations and evolution story,


— Host and Gut microbiota Interaction


Several studies, included our discovery, already proved that gut microbiota composition in adults can be viewed as a complex, polygenic trait with a synergy of host genetic and environmental factors. In our previous studies, we introduced heritability as an indicator to estimate the contributions from the host genetic variation. Alter those genes’ frequency would influence the interaction between specific gut microbiota. Currently, we investigate in how host genetic variation not only influence the composition of gut microbiota, but also the alternation cause the improvement of function performance of microbiota by enrich the abundance of relative microbiota.

 


PUBLICATIONS

 

  1. Shuyun Liu, Lele Zhao, Zhengxiao Zhai, Wenjing Zhao, Jinmei Ding. Ronghua Dai, Tao Sun, He Meng*. Porcine Epidemic Diarrhea Virus Infection Induced the Unbalance of Gut Microbiota in Piglets. Curr Microbiol,2015, DOI 10.1007/s00284-015-0895-6.
  2. Wenjing Zhao, Yapeng Wang, Shuyun Liu, Jiaojiao Huang, Zhengxiao Zhai, Chuan He, Jinmei Ding, Jun Wang, Huijuan Wang, Weibing Fan, Jianguo Zhao, He Meng*. The Dynamic Distribution of Porcine Microbiota across Different Ages and Gastrointestinal Tract Segments. Plos one, 2015, DOI:10.1371/journal.pone.0117441
  3. Zhengxiao Zhai, Wenjing Zhao, Chuan He, Kaixuan Yang, Linlin Tang, Shuyun Liu, Yan Zhang, Qizhong Huang and He Meng*. SNP discovery and genotyping using restriction-site-associated DNA sequencing in chickens. Animal Genetics, 2014, doi: 10.1111/age.12250.
  4. He Meng*, Yan Zhang *, Lele Zhao , Wenjing Zhao , Chuan He , Christa F. Honaker ,Zhengxiao Zhai , Zikui Sun , Paul B. Siegel*. Body Weight Selection Affects Quantitative Genetic Correlated Responses in Gut Microbiota. Plos one. 2014 , 9 (3): e89862
  5. Na Qiao , Qi Liua, He Meng* , Dayun Zhao*.Haemolytic activity and adjuvant effect of soyasaponins and some of their derivatives on the immune responses to ovalbumin in mice. International Immunopharmacology.2014,18: 333–339
  6. Jinlong Huang, Yiping Zhao, Dongyi Bai, Wunierfu Shiraigol1, Bei Li1, Lihua Yang, Jing Wu, Wuyundalai Bao, Xiujuan Ren, Burenqiqige Jin, Qinan Zhao, Anaer Li,Sarula Bao, Wuyingga Bao, Zhencun Xing, Aoruga An, Yahan Gao, Ruiyuan Wei,Yirugeletu Bao, Taoketao Bao, Haige Han, Haitang Bai, Yanqing Bao, Yuhong Zhang,Dorjsuren Daidiikhuu, Wenjing Zhao, Shuyun Liu, Jinmei Ding, Weixing Ye, Fangmei Ding, Zikui Sun, Yixiang Shi, Yan Zhang*, He Meng *& Manglai Dugarjaviin*. Donkey genome and insight intothe imprinting of fast karyotype evolution. Scientific Reports.2015, 5:14106, DOI: 10.1038/srep14106.
  7. Jinlong Huang, Yiping Zhao, Wunierfu Shiraigol, Bei Li, Dongyi Bai, Weixing Ye,Dorjsuren Daidiikhuu, Lihua Yang, Burenqiqige Jin, Qinan Zhao, Yahan Gao, Jing Wu,Wuyundalai Bao, Anaer Li, Yuhong Zhang, Haige Han, Haitang Bai, Yanqing Bao, Lele Zhao,Zhengxiao Zhai, Wenjing Zhao, Zikui Sun, Yan Zhang, He Meng & Manglai Dugarjaviin*. Analysis of horse genomes providesinsight into the diversification andadaptive evolution of karyotype. Scientific Reports. 2014, 4 : 4958, DOI: 10.1038/srep04958.
  8. Lele Zhao, Gang Wang, Paul Siegel, Chuan He, Hezhong Wang, Wenjing Zhao, Zhengxiao Zhai, Fengwei Tian, Jianxin Zhao, Hao Zhang, Zikui Sun, Wei Chen, Yan Zhang& He Meng*. Quantitative Genetic Background of the Host Influences Gut Microbiomes in Chickens. Scientific Reports. 2013, 3:1163. doi:10.1038/srep01163.
  9. Jirimutu, Zhen Wang, Guohui Ding, Gangliang Chen, Yamin Sun, Zhihong Sun, Heping Zhang, Lei Wang, Surong Hasi, Yan Zhang, Jianmei Li, Yixiang Shi, Ze Xu, Chuan He, Siriguleng Yu, Shengdi Li, Wenbin Zhang, Mijiddorj Batmunkh, Batsukh Ts, Narenbatu, Unierhu, Shirzana Bat-Ireedui, Hongwei Gao, Banzragch Baysgalan, Qing Li, Zhiling Jia, Turigenbayila, Subudenggerile, Narenmanduhu, Zhaoxia Wang, Juan Wang, Lei Pan, Yongcan Chen, Yaichil Ganerdene, Dabxilt, Erdemt, Altansha, Altansukh, Tuya Liu, Minhui Cao, Aruuntsever, Bayart, Hosblig, Fei He, A Zha-ti, Guangyong Zheng, Feng Qiu, Zikui Sun, Lele Zhao, Wenjing Zhao, Baohong Liu, Chao Li, Yunqin Chen, Xiaoyan Tang, Chunyan Guo, Wei Liu, Liang Ming, Temuulen, Aiying Cui, Yi Li, Junhui Gao, Jing Li, Wurentaodi, Shen Niu, Tao Sun, Zhengxiao Zhai, Min Zhang, Chen Chen, Tunteg Baldan, Tuman Bayaer, Yixue Li & He Meng*. Genome sequences of wild and domestic bactrian camels. Nature Communications. 2012 ,3:1202. doi: 10.1038/ncomms2192.
  10. Rina Wu1, Weiwei Wang, Dongliang Yu, Wenyi Zhang, Yan Li, Zhihong Sun, Junrui Wu, He Meng* & Heping Zhang1*.Proteomic Analysis of Lactobacillus casei Zhang, a New Probiotic Bacterium Isolated from Traditional Home-made Koumiss in Inner Mongolia of China. Molecular & Cellular Proteomics,2009,8(10) 2321-2338.
  11. Rimutu Ji, Peng Cui, Feng Ding, Jianing Geng, Hongwei Gao, Heping Zhang, Jun Yu, Songnian Hu, and He Meng*.Monophyletic Origin of Domestic Bactrian Camel (Camelus bactrianus) and Evolutionary Relationship with the Extant Wild Camel (Camelus bactrianus ferus). Animal genetics,2009,40:377-382.
  12. Kaixuan Yang, Yongcan Chen, Caiju Gu, Zhenxiang Zhou,Chuan He, Linlin Tang, Shiyu Li, Lele Zhao, He Meng*and Qizhong Huang*. Polydactyly mutation is linked to chromosome 2p region in Beijing fatty chicken. Animal Genetics.2012, doi: 10.1111/j.1365-2052.2012.02369.x
  13. Wenyi Zhang,Dongliang Yu, Zhihong Sun, Rina Wu, Xia Chen, Wei Chen, He Meng*，Songnian Hu, and Heping Zhang*.Complete Genome Sequence of Lactobacillus casei Zhang, a New Probiotic Strain Isolated from Traditional Homemade Koumiss in Inner Mongolia China. Journal of Bacteriology. 2010,190（19）：5268–5269.
  14. Rina Wu, Wenyi Zhang, Tiansong Sun, Junrui Wu, Xiqing Yue, He Meng*, Heping Zhang*. Proteomic analysis of responses of a new probiotic bacterium Lactobacillus casei Zhang to low acid stress. International Journal of Food Microbiology.2011, 147:181–187.
  15. Jicheng Wang , Zhi Zhong , Wenyi Zhang , Qiuhua Bao , Aibin Wei , He Meng *, Heping Zhang *.Comparative analysis of the gene expression profile of probiotic Lactobacillus casei Zhang with and without fermented milk as a vehicle during transit in a simulated gastrointestinal tract. Research in Microbiologoy. 2012. 10.1016 /j.resmic..04.002.
  16. Ji-Cheng Wang.Wen-Yi Zhang.Zhi Zhong.Ai-Bin Wei.Qiu-Hua Bao.Yong Zhang.Tian-Song Sun.Andrew PostnikoV. He Meng*.He-Ping Zhang*. Transcriptome analysis of probiotic Lactobacillus casei Zhang during fermentation in soymilk. Journal of Industrial Microbiology and Biotechnology. 2011, DOI 10.1007/s10295-011-1015-7.
  17. Jicheng Wang, Wenyi Zhang, Zhi Zhong, Aibin Wei, Qiuhua Bao, Yong Zhang,Tiansong Sun , Andrew Postnikoff, He Meng*, Heping Zhang*. Gene expression profile of probiotic Lactobacillus casei Zhang during the late stage of milk fermentation. Food Control.2012, 25:321-327.
  18. R. Wu, Z. Sun, J. Wu, H. Meng*, H. Zhang*,Effect of bile salts stress on protein synthesis of Lactobacillus casei Zhang revealed by 2-dimensional gel electrophoresis. Journal of Dairy Science.2010,93(8): 3858-3868. 
  19. Zhi Zhong , Wenyi Zhang , Ruiting Du , He Meng *, Heping Zhang *. Lactobacillus casei Zhang stimulates lipid metabolism in hypercholesterolemic rats by affecting gene expression in the liver. European Journal of Lipid Science and Technology. 2011, DOI: 10.1002/ ejlt. 201100118.
  20. L. H. Zhu, H. Meng*, X. J. Duan, G. Q. Xu, J. Zhang, and D. Q. Gong*. Gene expression profile in the liver tissue of geese after overfeeding. Poultry Science. 2010,90:107-117.
  21. H. Meng，H. Li， J.G. Zhao， Z.L.Gu.Differential expression of peroxisome proliferator activated receptors alpha and gamma gene in various chicken tissues. Domestic Animal Endocrinology.2005,28: 105-110.
  22. Wen Yi Zhang, Zhi Hong Sun,Dong Liang Yu, Caicike Airideng, Wei Chen, He Meng* ,He Ping Zhang*.Comparative analysis of iol clusters in Lactobacillus casei strains. World J Microbiol Biotechnol.2010,26:1949–1955.
  23. XIA CHEN,ZHIHONG SUN, HE MENG* and HEPING ZHANG*.The acid tolerance association with expression of H+-ATPase in Lactobacillus casei. International Journal of Dairy Technology. 2009, 62( 2 ):272-276.
  24. Zhang, W.,  D. Yu,  Z. Sun, W. Chen, S. Hu, H. Meng* and H. Zhang*.The comparative analysis of a prophage remnant Lcazh1 in relation to other Lactobacillus prophages, particularly Lp3. International Journal of Dairy Technology.2010,63（1）： 1-5.
  25. H. Meng, H. Li , J.G. Zhao, Z. H. Li.Single Nucleotide Polymorphisms on Peroxisome Proliferator-activated Receptor Genes Associated with Fatness Traits in Chicken. Asian-Australasian Journal of Animal Sciences.2005,18(9):1221-1225.
  26. Wen Yi ZHANG, Ri Na WU, Zhi Hong SUN, Tian Song SUN, He MENG*, He Ping ZHANG*.Molecular cloning and characterization of bile salt hydrolase in Lactobacillus casei Zhang. Annals of Microbiology. 2009, 59 (4) 721-726.
  27. Wen Yi ZHANG, Dong Liang YU, Zhi Hong SUN, Caicike AIRIDENG, Song Nian HU, He MENG*,He Ping ZHANG*.Preliminary analysis of glutathione S-transferase homolog from Lactobacillus casei Zhang. Annals of Microbiology. 2009,59 (4) 727-731. 
  28. H. MENG, F.Y. CUI, X.H. CHEN, Y.C. PAN.Inhibition of gene expression directed by small interfering RNAs in infectious bronchitis virus. Acta virologica.2007,51(4):265-269.
  29. Biao Dong,  Daoqing Gong, Zhiliang Gu, He Meng*. Molecular cloning and characterization of Rab6 gene in duck. DNA Sequence.2007,18 ( 4) :307 – 311.
  30. Xia CHEN, Zhi Hong SUN, He MENG*, He Ping ZHANG*.Molecular cloning and characterisation of gamma subunit of H+-ATPase in Lactobacillus acidophilus MG2-9. Annals of Microbiology. 2007, 57(3);415-418.
  31. Peng Cui, Rimutu Ji, Feng Ding, Dan Qi, Hongwei Gao, He Meng, Jun Yu,Songnian Hu, and Heping Zhang. A complete mitochondrial genome sequence of the wild two-humped camel (Camelus bactrianus ferus): an evolutionary history of camelidae. BMC Genomics. 2007,8 (241):1-10.
  32. Zhihong Sun, Xia Chen, Jicheng Wang, Pengfei Gao, Zhemin Zhou,Yi Ren,Tiansong Sun,Lei Wang, He Meng, Wei Chen* and Heping Zhang*. Complete Genome Sequence of Probiotic Bifidobacterium animalis subsp. lactis Strain V9. Journal of Bacteriology.2010,192(15): 4080-4081.
  33. Zhang, W., Yu, D., Sun, Z., Chen, X., Bao, Q., Meng, H., Hu, S., and Zhang, H. Complete nucleotide sequence of plasmid plca36 isolated from Lactobacillus casei Zhang. Plasmid. 2008,60(2):131-135.
  34. Jian-Guo Zhao, Hui Li, Yu-Xiang Wang, He Meng*. The Expression Characterization of Chicken Uncoupling Protein Gene. Asian-Australasian Journal of Animal Sciences. 2005,18(11) : 1552 -1557.
  35. Chen X., Yang M., Sun Z., Liu W., Sun T., Meng H., Zhang H. Molecular Cloning and Characterisation of Alpha Subunit of H+-ATPase in Lactobacillus casei Zhang. Czech Journal of food sciences.2009,27( 1 ): 49–54.
  36. Chunyan Bai, He Meng, Wei Zhao, Yuchun Pan. Molecular cloning and characterization of monoamine oxidase A and B genes in pig. DNA Sequence.2005,16(3): 161–165.
  37. Yu, Dandan; Meng, He; Bai, Chunyan; Zhao, W.; Wang, Q. S.; Pan, Yuchun. Molecular cloning of nuclear receptor coactivator-1 gene in pig. DNA Sequence.2006,17(1):79-82.
  38. C.L. Li, Y.C. Pan and H. Meng. Polymorphism of the H-FABP, MC4R and ADD1 genes in the Meishan and four other pig populations in China. South African Journal of Animal Science.2006,36 (1) :1-6.
  39. LI Chang-long,PAN Yu-chun, Meng He, LI Jing, WANG Qi-shan. Cloning, Sequencing, and Characterization of Porcine Sterol Regulatory Element Binding Proteins-1c Gene. Journal of Shanghai Jiaotong University ( Science) , 2005,E-10, S1, 072～076.


* Corresponding author

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