授课人:何跃辉, 北京大学(中科院上海植物逆境科学研究中心),研究员
时间:12月14日,星期一,18:00-20:20
地点:陈瑞球楼304
授课教师简介
1997-2001,肯塔基大学 (University of Kentucky, USA),博士
2001-2005, 威斯康星大学麦迪逊分校,博士后
2005 - 2014,新加坡国立大学,助理教授、副教授
2006 - 2014,新加坡淡马锡生命科学研究所,研究员
2013.6-至今, 中科院上海植物逆境科学研究中心
研究工作
何跃辉研究员多年聚焦环境信号 (光周期和冬季低温) 调控植物开花时间(flowering time)的分子与表观遗传机理。开花时间受多种内在(如年龄、激素等)与外源环境因子(如季节变化、温度等)的调控。这些因素通过多种遗传途径如光周期路径、春化路径、年龄路径等,调控开花时间基因的表达,从而诱导植物开花。课题组目前的研究主要利用模式开花植物拟南芥,采用分子、生化、遗传及组学的手段,聚焦春化路径及光周期路径,探索季节变化调控越冬植物在春季开花的分子与表观遗传机制。
代表性论文
1. Tao Z, Hu H, Luo X, Jia B, Du J, He Y. (2019) Embryonic resetting of the parental vernalized state by two B3 domain transcription factors in Arabidopsis. Nature Plants, 5: 424-435.
2. Luo X, Chen T, Zeng X, He D, He Y. (2019) Feedback regulation of FLC by FLOWERING LOCUS T and FD through a 5' FLC promoter region. Molecular Plant, 12: 285-288.
3. Li Z, Fu X, Wang Y, Liu R and He Y. (2018) Polycomb-mediated gene silencing by the BAH-EMF1 complex in plants. Nature Genetics, 50: 1254-1261.
4. Li Z, Jiang D and He Y. (2018) FRIGIDA establishes a local chromosomal environment for FLOWERING LOCUS C mRNA production. Nature Plants, 4: 836-846.
5. Z. Li, Y. Ou, J. Li and He Y. (2018) Brassinosteroid signaling recruits Histone 3 lysine-27 demethylation activity to FLOWERING LOCUS C chromatin to inhibit the floral transition in Arabidopsis. Molecular Plant, 11: 1135-1146.
6. Y. He & Li Z. (2018) Epigenetic environmental memories in plants: establishment, maintenance, and reprogramming. Trends in Genetics, 34: 856-866.
7. Z. Tao, L. Shen, X. Gu, Y. Wang, H. Yu & He Y. (2017) Embryonic epigenetic reprogramming by a pioneer transcription factor in plants. Nature, 551: 124–128.
8. Yuan W, Luo X, Li Z, Yang W, Wang Y, Liu R, Du J & He Y. (2016) A cis cold memory element and a trans epigenome reader mediate Polycomb silencing of FLC by vernalization in Arabidopsis. Nature Genetics, 48: 1527-34.
9. Li Z, Jiang D, Fu X, Luo X, Liu R & He Y. (2016) Integration of histone methylations with RNA processing by the nuclear mRNA Cap Binding Complex. Nature Plants, 2: 16015.
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