PI组长：

李新红  教授/博士生导师    

主要研究领域：

1. 生殖细胞蛋白修饰功能及调控

2. 生殖细胞低温保存技术

3. 生殖毒理分子机制

PI研究组代表性成果：

主要研究方向：

1、动物生殖细胞蛋白质修饰功能研究：基于动物生殖细胞宏观表征及繁殖潜能特性，以生殖细胞蛋白磷酸化、酰化修饰功能以及相关生物信息学功能分析为主要研究策略，研究生殖细胞蛋白酰化修饰的功能及调控机制，筛选繁殖潜能相关调节蛋白及修饰标记分子。

2、动物繁殖障碍分子机制：基于生殖细胞的多组学研究，探讨病菌、重金属等环境污染物诱导生殖细胞基因变异、蛋白及修饰特征变化以及相关分子机制。基于分子、细胞及动物水平，开展分子标志物和靶点的功能学研究，解析病菌、重金属等环境污染物影响生殖细胞发生发展的关键基因、蛋白修饰及信号通路，探究生殖细胞损伤及动物繁殖障碍的分子诊疗指标体系。

3、家畜动物生殖细胞体外低温保存调控技术：针对家畜动物繁殖生产技术瓶颈，利用生殖细胞代谢通路关键因子活性调控技术，揭示家畜动物生殖细胞体外低温保存维持活性的核心分子机制；结合生殖细胞代谢组学、蛋白修饰组学等表型研究，解析蛋白修饰与生殖细胞表观活性的关联性，挖掘与维持细胞活性相关的分子标志物，开展相关机理及应用技术研究。

 

近期代表性论文：

1. Li Xinhong*, Lirui Wang, Jieli Fu, Linqing Zhen, Yuhua Li, Yaozhong Zhang, Yafei Zhang*. C₆₀ Fullerenes Suppress Reactive Oxygen Species Toxicity Damage in Boar Sperm. Nano Micro Letter. 2019, 11:104 (IF:12.264)；

2. Yang Qiangzhen, Xunrui Liu, Jun Chen,Yi Wen, Huan Liu, Zijun Peng, Yeerken Ran, Lirui Wang, Xinhong Li*. Lead-mediated inhibition of lysine acetylation and succinylation causes reproductive injury of the mouse testis during development. Toxicology Letter. 2020. 318:30-43.  (IF:3.499)；

3. Fu Jieli, Qiangzhen Yang, Yuhua Li, Peifei Li, Lirui Wang, Xinhong Li*. A mechanism by which Astragalus polysaccharide protects against ROS toxicity through inhibiting the protein dephosphorylation of boar sperm preserved at 4 °C. J Cell Physiol. 2018, 233(7):5267-5280. ( IF: 4.522 )；

4. Yang Qiangzhen, Peifei Li, Yi Wen, Sisi Li, Jun Chen, Xunrui Liu, Lirui Wang, Xinhong Li* Cadmium inhibits lysine acetylation and succinylation inducing testicular injury of mouse during development. Toxicology Letter. 2018, 291:112-120. (IF:3.499)；

5. Wang Lirui, Peifei Li, Yi Wen, Qiangzhen Yang, Linqing Zhen, Jieli Fu, Yuhua Li, Sisi Li, Xinhong Li*. Vitamin C exerts novel protective effects against cadmium toxicity in mouse spermatozoa by inducing the dephosphorylation of dihydrolipoamide dehydrogenase. Reproductive Toxicology. 2018, 75:23-32. (IF:3.20)；

6. Li Xinhong*, Linqing Zhen, Jieli Fu, Lirui Wang, Qiangzhen Yang, Peifei Li, Yuhua Li. Quantitative Proteomic Profiling Indicates the Difference in Reproductive Efficiency Between Meishan and Duroc Boar Spermatozoa. Theriogenology, 2018, 116:71-82 (IF: 2.228)；

7. Li Peifei, Qiangzhen Yang, Sisi Li, Hao Sun, Huan Liu, Bushe Li, Qingwei Cui, Xinhong Li*. Candidates for reproductive biomarkers: protein phosphorylation and acetylation positively related to parameter of boar spermatozoa quality. Animal Reproduction Science. 2018, 197: 67-80. (IF:1.817)；

8. Fu Jieli, Yuhua Li, Llirui Wang, Linqing Zhen, Qiangzhen Yang, Peifei Li, Xinhong Li*. Bovine serum albumin and skim-milk improve boar sperm motility by enhancing energy metabolism and protein modifications during liquid storage at 17 °C. Theriogenology. 2017, 102:87-97. (IF:2.285)；

9. Li Xinhong*, Lirui Wang, Yuhua Li, Jieli Fu, Linqing Zhen, Qiangzhen Yang, Sisi Li. Tyrosine phosphorylation of dihydrolipoamide dehydrogenase as a potential cadmium target and its inhibitory role in regulating mouse sperm motility. Toxicology. 2016, 357 : 52-64. (IF:3.581)；

10. Zhen Linqing, Lirui Wang, Jieli Fu, Yuhua Li, Na Zhao, Xinhong Li*. Hexavalent chromium affects sperm motility by influencing protein tyrosine phosphorylation in the midpiece of boar spermatozoa. Reproductive Toxicology. 2016, 59 : 66-79. (IF:3.05)；

11. Wang Lirui, Yuhua Li, Jieli Fu, Linqing Zhen, Na Zhao, Qiangzhen Yang, Sisi Li, Xinhong Li*. Cadmium inhibits mouse sperm motility through inducing tyrosine phosphorylation in a specific subset of proteins. Reproductive Toxicology. 2016, 63 : 96-106. (IF:3.05)；

12. Li Xinhong*, Lirui Wang, Yuhua Li, Na Zhao, Linqing Zhen, Jieli Fu, Qiangzhen Yang. Calcium regulates motility and protein phosphorylation by changing cAMP and ATP concentrations in boar sperm in vitro. Animal Reproduction Science. 2016, 172 : 39-51. (IF:1.647)；